Why rats (and humans) addicted to alcohol may not respond to psilocybin treatment
In our paper, we show how severity of alcohol relapse in rats can affect psilocybin’s mode of action
TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC
This study identified the significant role of TRAIP in inhibiting BLCA progression, and revealed that TRAIP expression is significantly downregulated in BLCA and is strongly associated with poor prognosis.
DeepRTAlign: toward accurate retention time alignment for large cohort mass spectrometry data analysis
Retention time (RT) alignment is a crucial step in large cohort proteomics and metabolomics studies. Here, the authors introduce DeepRTAlign, a deep learning tool for RT alignment that shows high identification sensitivity and quantitative accuracy.
Body mass index, triglyceride-glucose index, and prostate cancer death: a mediation analysis in eight European cohorts
Analyzing data of over 250,000 European men, the TyG index, an indicator of insulin resistance, mediated part of the effect of BMI on prostate cancer death, thus supporting the hypothesis that insulin resistance might be an important pathway for obesity to accelerate prostate cancer progression.