Printed Nanomembrane Wireless Bioelectronics

We report an additive nanomanufacturing process that yields all-printed nanomaterial-based wireless electronics for human-machine interfaces.

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One and a half years ago, we got a question of how to manufacture high-performance, flexible, and wearable bioelectronics without the use of the conventional cleanroom fabrication processes. This paper, entitled All-printed nanomembrane wireless bioelectronics using a biocompatible solderable graphene for multimodal human-machine interfaces, answers the initial question that we had via the development of a new class of an additive nanomanufacturing.

This work shows the first demonstration of all-printed, nanomembrane, wireless soft electronics using multiple nanomaterials to construct high-performance sensors and circuits. New findings and advanced engineering of nanoparticle printing methods (Fig. 1) offer a unique way of nanodevice fabrication, which avoids using any cleanroom facility, layer-by-layer photolithography, or multi-step transfer printing.

Fig. 1 Schematic illustrations of printing of aerosol nanoparticles from polyimide (PI), silver (Ag), and functional conductive graphene (FCG) inks to construct a multi-layered structure. The atomized droplets in a nitrogen gas stream are directed to the print head to draw desired patterns on a flexible substrate.

 

One of the key technological advancements is using a functionalized conductive graphene with enhanced biocompatibility, anti-oxidation, and solderability, which allows us to build a wireless, high-performance flexible circuit. The high-aspect-ratio graphene, laminated on an elastomeric membrane, offers gel-free, high-fidelity recording of muscle activities on the forearm. In addition, anatomical study with deep learning-embedded electrophysiology mapping allows for an optimal selection of three sensor channels to successfully capture all finger motions with an accuracy of about 99% for seven classes (Fig. 2).

Fig. 2 a, Schematic illustration (top) showing target muscles on the forearm to recognize multiple gestures and photos (bottom) capturing three bioelectronics. b, Mapping data showing muscle signals from multiple channels that cover the entire forearm; six different heat maps are obtained according to six gestures, including hand closed, thumb, index, middle, ring, and little finger motion. c, Demonstration of a wireless, wearable device to precisely control a flying drone (left), RC car (middle), and presentation software (right). d, 3D plot of three-channel, muscle signals for clear differentiation of seven different gestures. e, Summarized result of real-time, confusion matrix from ten trials, showing ~99% accuracy across seven classes.

 

Collectively, this paper represents a major shift in how additive nanomanufacturing can be used for building wireless flexible nanoelectronics and persistent human-machine interfaces when combined with deep learning algorithms.

For more details about our journey, please see the published article in Nature Communications or email Dr. Yeo directly at whyeo@gatech.edu :

All-printed nanomembrane wireless bioelectronics using a biocompatible solderable graphene for multimodal human-machine interfaces

 

 

 

 

Woon-Hong Yeo

Assistant Professor, Georgia Institute of Technology

Dr. Yeo has established a strong research program in the fields of nanoengineering and human-machine interfaces. The goal of Dr. Yeo’s research is to understand the fundamentals of soft materials, deformable mechanics, biological interface forces, and nanomanufacturing for the development of stretchable nanomembrane biosensors and bioelectronics. The comprehensive study of bioelectronic systems aims to advance human healthcare, disease diagnostics, therapeutics, and human-machine interactions. Please visit Dr. Yeo's website to see the details: HTTP://yeolab.gatech.edu

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